Zoledronate-pulsed dendritic cell-based anticancer vaccines

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Zoledronate-pulsed dendritic cell-based anticancer vaccines

The addition of zoledronate to tumor-associated antigen (TAA)-loaded dendritic cells (DCs) promotes the activation of interferon γ-secreting Vγ9 γδ T cells, in turn eliciting TAA-specific CD8+ T-cell responses. Immunological responses induced by zoledronate-pulsed DC-based vaccines have been associated with therapeutic effects in clinical trials.

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ژورنال

عنوان ژورنال: OncoImmunology

سال: 2013

ISSN: 2162-402X

DOI: 10.4161/onci.25636